Aromaticity study of heterocyclic anticancer compounds through computational s-nics method

Anticancer bisquaternary heterocyclic compounds: a ras-ional design.

A new family of symmetrical bisquaternary compounds with semirigid linkers have shown to be highly specific for Choline Kinase (ChoK) inhibition and to exert antitumoural activity in cell lines and in mice. A three-parameter regression equation has been derived which satisfactorily describes the ex vivo inhibitory potency of ChoK of the title compounds. The electronic effect of the group at pos...

HUCKEL (4n+2) RULE FOR AROMATICITY 1.4. AROMATICITY OF BENZENOID AND HETEROCYCLIC COMPOUNDS 1.4.1. BENZENOID COMPOUNDS 1.4.1.1. Six-membered rings 1.4.1.2. Phenanthrene and anthracene 1.4.1.3. Heterocyclic compounds 1.4.2. NON-BENZENOID AROMATIC COMPOUNDS

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Aromaticity as a cornerstone of heterocyclic chemistry.

Computational study of Anticancer Dasatinib for drug delivery systems

Dasatinib is a tyrosine kinase inhibitor (TKI) that is used to treat chronic myeloid leukemia and in the management of ulcerative colitis (UC) and to provide appropriate results in treatment. Dasatinib is significantly higher and faster than full cytogenetic and large molecular responses as compared to imatinib. In the recent study, using the NMR data, the frequency and thermochemical propertie...

Computational Study of Anticancer Dasatinib for Drug Delivery Systems

Dasatinib is a tyrosine kinase inhibitor (TKI) that is used to treat chronic myeloid leukemiaand in the management of ulcerative colitis (UC) and to provide appropriate results in treatment. Dasatinib is significantly higher and faster than full cytogenetic and large molecular responses as compared to imatinib. In the recent study, using the NMR data, thermochemical properties of the dasa...